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| Nonne–Milroy–Meige syndrome ： ウィキペディア英語版 |
Milroy's disease
Milroy's disease is a familial disease characterized by lymphedema, commonly in the legs, caused by congenital abnormalities in the lymphatic system. Disruption of the normal drainage of lymph leads to fluid accumulation and hypertrophy of soft tissues. It is also known as Milroy disease, Nonne-Milroy-Meige syndrome and hereditary lymphedema.
It was named by Sir William Osler for William Milroy, an American physician, who described a case in 1892, though it was first described by Rudolf Virchow in 1863.〔W. F. Milroy. An undescribed variety of herditary edema. New York Medical Journal, 1892, 56: 505-508.〕
==Description==
The most common presentation of Milroy Disease is bilateral lower extremity lymphedema, and may also be accompanied by hydrocele.〔(【引用サイトリンク】url=http://ghr.nlm.nih.gov/condition/milroy-disease )〕
This disease is more common in women and an association with the gene FLT4 has been described. FLT4 codes for VEGFR-3, which is implicated in development of the lymphatic system.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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